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Comprehensive and trusted information about Doxycycline hyclate - plus advice on 24000 other FDA approved drugs and medications from Drugs. com. Accurate, FDA approved Doxycycline Hyclate information for healthcare professionals and patients - brought to you by Drugs. com. Learn the indications and dosage for Doryx (Doxycycline Hyclate) and other prescription drugs and medications at RxList. Find Doryx (Doxycycline Hyclate) medication description and details on prescription drugs. I took Doxycycline Hyclate one night before going to bed. Big mistake. It was still in my throat when I woke up the next morning. . This is my second round with Doxycycline for a Staph infection (probably MRSA - the culture isn't back yet); the first round was. 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